Discrete event simulation for the purpose of real-time performance evaluation of distributed hardware-in-the-loop simulators for autonomous driving vehicle validation

Hardware-in-the-loop test benches are distributed computer systems including software, hardware and networking devices, which require strict real-time guarantees. To guarantee strict real-time of the simulator the performance needs to be evaluated. To evaluate the timing performance a discrete event simulation model is built up. The input modeling is based on measurements from the real system in a prototype phase. The results of the simulation model are validated with measurements from a prototype of the real system. The workload is increased until the streaming source becomes unstable, by either exceeding a certain limit of bytes or exceeding the number of parallel software processes running on the cores of the central processing unit. To evaluate the performance beyond these limits, the discrete event simulation model needs to be enriched by a scheduler and a hardware model. To provide real-time guarantees an analytical model needs to be built up

Ensuring Reliable and Predictable Behavior of IEEE 802.1CB Frame Replication and Elimination

Ultra-reliable and low-latency communication has received significant research attention. A key part of this evolution are the Time-Sensitive Networking (TSN) standards, which extend Ethernet with real-time mechanisms. To guarantee high reliability, the standard IEEE 802.1CB-2017 Frame Replication and Elimination for Reliability enables redundant communication over disjoint paths. While this mechanism is essential for time-critical applications, the standard contains some fundamental limitations that can compromise safety. Although some of these limitations have been addressed, none of the previous works provide solutions to these problems. This paper presents solutions to four main limitations of the IEEE 802.1CB-2017 standard. These are 1) choosing match versus vector recovery algorithm, 2) defining the length of the sequence history, 3) setting a timer to reset the sequence history, and 4) dimensioning the burst size in case of link failures. We show how these challenges can be solved by using best- and worst-case path delays of the network. We have performed simulations to illustrate the impact of the limitations and prove the correctness of our solutions. Thereby, we demonstrate how our solutions can improve reliability in TSN networks and propose these methods as guidance for users of the IEEE 802.1CB standard

From Simulation Data to Test Cases for Fully Automated Driving and ADAS

Part 3: Practical Applications International audience Within this paper we present a new concept on deriving test cases from simulation data and outline challenging tasks when testing and validating fully automated driving functions and Advanced Driver Assistance Systems (ADAS). Open questions on topics like virtual simulation and identification of relevant situations for consistent testing of fully automated vehicles are given. Well known criticality metrics are assessed and discussed with regard to their potential to test fully automated vehicles and ADAS. Upon our knowledge most of them are not applicable to identify relevant traffic situations which are of importance for fully automated driving and ADAS. To overcome this limitation, we present a concept including filtering and rating of potentially relevant situations. Identified situations are described in a formal, abstract and human readable way. Finally, a situation catalogue is built up and linked to system requirements to derive test cases using a Domain Specific Language (DSL). Document type: Part of book or chapter of boo

MMBnet 2017 - Proceedings of the 9th GI/ITG Workshop „Leistungs-, Verlässlichkeits- und Zuverlässigkeitsbewertung von Kommunikationsnetzen und Verteilten Systemen“

Nowadays, mathematical methods of systems and network monitoring, modeling, simulation, and performance, dependability and reliability analysis constitute the foundation of quantitative evaluation methods with regard to software-defined next-generation networks and advanced cloud computing systems. Considering the application of the underlying methodologies in engineering practice, these sophisticated techniques provide the basis in many different areas. The GI/ITG Technical Committee “Measurement, Modelling and Evaluation of Computing Systems“ (MMB) and its members have investigated corresponding research topics and initiated a series of MMB conferences and workshops over the last decades. Its 9th GI/ITG Workshop MMBnet 2017 „Leistungs-, Verlässlichkeits- und Zuverlässigkeitsbewertung von Kommunikationsnetzen und Verteilten Systemen“ was held at Hamburg University of Technology (TUHH), Germany, on September 14, 2017. The proceedings of MMBnet 2017 summarize the contributions of one invited talk and four contributed papers of young researchers. They deal with current research issues in next-generation networks, IP-based real-time communication systems, and new application architectures and intend to stimulate the reader‘s future research in these vital areas of modern information society

Early detection of duodenal cancer by upper gastrointestinal-endoscopy in Lynch syndrome

Small bowel cancer (SBC) is the malignancy with the highest standardized incidence ratio in Lynch syndrome (LS) patients. Of all SBCs, about 50% are duodenal cancers (DCs), therefore being accessible by esophago-gastro-duodenoscopy (EGD) for surveillance. We asked whether early detection of DC is possible for LS patients undergoing surveillance by EGD and if surveillance should be limited to specific subgroups. Data for LS patients with DC were retrieved from the registry of the German Consortium for Familial Intestinal Cancer. Patients undergoing active surveillance by EGDs (surveillance group) were compared to those who did not (nonsurveillance group) regarding tumor stage at diagnosis. Union for International Cancer Control stages I-IIA were defined as early stage disease and IIB-IV as advanced stage disease. Statistical analysis was performed using Fisher's exact test. Among 2015 patients with pathogenic variants in any mismatch-repair-gene, 47 patients with 49 DCs were identified. In 10% of cases, patients were under 35 years at diagnosis; family and personal tumor history did not correlate with DC diagnosis. Pathogenic germline variants in MSH6, PMS2 or EPCAM were present in 10% of patients. Statistical analysis could be performed on 13 DC patients in the surveillance group and 14 in the nonsurveillance group. Early detection was possible for 71% of patients in the surveillance group and 29% of patients in the nonsurveillance group (P = .021). Early detection of DC by EGD in LS patients is feasible regardless of family history, mutational status and should start no later than 25 years of age

Adenoma and colorectal cancer risks in Lynch syndrome, Lynch-like syndrome and familial colorectal cancer type X

Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are different entities of familial cancer predisposition leading to an increased risk of colorectal cancer (CRC). The aim of this prospective study was to characterise and to compare the risks for adenoma and CRC in these three risk groups. Data was taken from the registry of the German Consortium for Familial Intestinal Cancer. Patients were prospectively followed up in an intensified colonoscopic surveillance programme that included annual examinations. Cumulative risks for adenoma and CRC were calculated separately for LS, LLS and FCCX, and then for males and females. Multivariate Cox regression was used to analyse the independent contributions of risk group, mismatch repair gene (within LS), sex and previous adenoma. The study population comprised 1448 individuals (103 FCCX, 481 LLS and 864 LS). The risks were similar for colorectal adenomas, but different for first and metachronous CRC between the three risk groups. CRC risk was highest in LS, followed by LLS and lowest in FCCX. Male sex and a prevalent adenoma in the index colonoscopy were associated with a higher risk for incident adenoma and CRC. In patients with LS, CRC risks were particularly higher in female MSH2 than MLH1 carriers. Our study may support the development of risk-adapted surveillance policies in LS, LLS and FCCX. What's new? While associations between colorectal cancer (CRC) risk and Lynch syndrome (LS) are well-described, less is known about CRC risks linked to the closely related Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX). In this prospective follow-up study of patients with LS, LLS, and FCCX, risks were similar for colorectal adenomas but considerably different for first and metachronous CRCs. In addition, LS females who carried MSH2 mutations had notably higher CRC risks than female MLH1 mutation carriers. The identification of variations in carcinogenic pathways between LS, LLS, and FCCX could enable risk-adapted CRC surveillance for these syndromes

Value of upper gastrointestinal endoscopy for gastric cancer surveillance in patients with Lynch syndrome

In our study, we evaluated the effectiveness of upper gastrointestinal (GI) endoscopy as an instrument for early gastric cancer (GC) detection in Lynch syndrome (LS) patients by analyzing data from the registry of the German Consortium for Familial Intestinal Cancer. In a prospective, multicenter cohort study, 1128 out of 2009 registered individuals with confirmed LS underwent 5176 upper GI endoscopies. Compliance was good since 77.6% of upper GI endoscopies were completed within the recommended interval of 1 to 3 years. Forty-nine GC events were observed in 47 patients. MLH1 (n = 21) and MSH2 (n = 24) mutations were the most prevalent. GCs in patients undergoing regular surveillance were diagnosed significantly more often in an early-stage disease (UICC I) than GCs detected through symptoms (83% vs 25%; P = .0231). Thirty-two (68%) patients had a negative family history of GC. The median age at diagnosis was 51 years (range 28-66). Of all GC patients, 13 were diagnosed at an age younger than 45. Our study supports the recommendation of regular upper GI endoscopy surveillance for LS patients beginning no later than at the age of 30. What's new? Risk of gastric cancer (GC) is significantly increased among patients with Lynch syndrome (LS). GC screening in LS patients, however, is fraught with uncertainty, particularly regarding the use of esophagogastroduodenoscopy (EGD). The authors of this study investigated the use of EGD for regular GC surveillance in a German cohort of LS patients. Regular surveillance by EGD resulted in more frequent diagnosis and significant down-staging of GC, relative to detection via symptoms alone. In most cases, family history of GC was negative. This study supports recommendations for regular gastroscopic surveillance in LS patients starting by age 30